埃及上埃及地区慢性丙型肝炎患者中隐匿性乙肝病毒感染的患病率
Prevalence of Occult HBV Infection Among Chronic Hepatitis C Patients in Upper Egypt.
作者信息
Thabit Amany G, Hassan Mona A, Agban Michael N, Makhlouf Nahed A, Khalil Nasr K, Hassan Hebat-Allah M, El-Mokhtar Mohamed A
机构信息
Department of Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Tropical Medicine & Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt.
出版信息
Egypt J Immunol. 2017 Jan;24(1):131-142.
Occult hepatitis B virusinfection (OBI) is defined as the presence of HBV DNA in liver or serum of individuals who test negative for hepatitis B surface antigen (HBsAg).We aimed at determining the prevalence of OBI in patients chronically infected with HCV in Upper Egypt and to evaluate the possible impact of OBI on the progression of the liver disease. This study included 200 chronic HCV infected patients. HBV DNA was detected in the serum of 21 patients (10.5%) by nested PCR. 13 of them were positive for anti-HBc. HBV viral load ranged from 4.2-60.1 IU/ml. The percentage of cirrhotics was higher among OBI/HCV dual infection (52.4%) versus HCV mono infection (34.1%). Our study concluded that the prevalence of OBI among chronic HCV patients in Upper Egypt was 10.5%. OBI correlated with the severity of liver disease. Total anti-HBc cannot be used as a surrogate marker for detection of OBI.
隐匿性乙型肝炎病毒感染（OBI）的定义为，乙肝表面抗原（HBsAg）检测呈阴性的个体肝脏或血清中存在HBV DNA。我们旨在确定上埃及慢性丙型肝炎病毒（HCV）感染患者中OBI的患病率，并评估OBI对肝病进展的可能影响。本研究纳入了200例慢性HCV感染患者。通过巢式PCR在21例患者（10.5%）的血清中检测到HBV DNA。其中13例抗-HBc呈阳性。HBV病毒载量范围为4.2 - 60.1 IU/ml。与HCV单一感染（34.1%）相比，OBI/HCV双重感染中肝硬化患者的比例更高（52.4%）。我们的研究得出结论，上埃及慢性HCV患者中OBI的患病率为10.5%。OBI与肝病严重程度相关。总抗-HBc不能用作检测OBI的替代标志物。
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