来自海洋甲藻卡特亚力山大藻的最大安福菌素同系物的结构及构效关系

Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure-Activity Relationships.

作者信息

Satake Masayuki, Cornelio Kimberly, Hanashima Shinya, Malabed Raymond, Murata Michio, Matsumori Nobuaki, Zhang Huiping, Hayashi Fumiaki, Mori Shoko, Kim Jong Souk, Kim Chang-Hoon, Lee Jong-Soo

机构信息

Department of Chemistry, School of Science, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Department of Chemistry, Graduate School of Science, Osaka University , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.

出版信息

J Nat Prod. 2017 Nov 22;80(11):2883-2888. doi: 10.1021/acs.jnatprod.7b00345. Epub 2017 Nov 9.

DOI:10.1021/acs.jnatprod.7b00345

PMID:29120640

Abstract

Amphidinols are polyketide metabolites produced by marine dinoflagellates and are chiefly composed of a long linear chain with polyol groups and polyolefins. Two new homologues, amphidinols 20 (AM20, 1) and 21 (AM21, 2), were isolated from Amphidinium carterae collected in Korea. Their structures were elucidated by detailed NMR analyses as amphidinol 6-type compounds with remarkably long polyol chains. Amphidinol 21 (2) has the longest linear structure among the amphidinol homologues reported so far. The congeners, particularly amphidinol 21 (2), showed weaker activity in hemolysis and antifungal assays compared to known amphidinols.

摘要

扁藻素是海洋甲藻产生的聚酮化合物代谢产物，主要由带有多元醇基团和聚烯烃的长线性链组成。从韩国采集的卡特氏扁藻中分离出两个新的同系物，扁藻素20（AM20，1）和扁藻素21（AM21，2）。通过详细的核磁共振分析确定它们的结构为具有显著长多元醇链的扁藻素6型化合物。扁藻素21（2）是迄今为止报道的扁藻素同系物中线性结构最长的。与已知的扁藻素相比，这些同系物，特别是扁藻素21（2），在溶血和抗真菌试验中表现出较弱的活性。