CNR, Istituto di Chimica Biomolecolare , Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy.
J Nat Prod. 2014 Jun 27;77(6):1524-7. doi: 10.1021/np500275x. Epub 2014 Jun 13.
Two new polyketides of the amphidinol family, amphidinol 18 (AM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae. Structure elucidation of the two polyoxygenated molecules has been accomplished by extensive use of spectroscopic and spectrometric techniques. AM18 exhibited antifungal activity against Candida albicans at 9 μg/mL.
从双鞭甲藻属（Amphidinium carterae）的甲醇提取物中分离得到两种新的 Amphidinol 家族聚酮化合物， Amphidinol 18（AM18，1）及其相应的 7-硫酸盐衍生物（AM19，2）。通过广泛使用光谱和光谱技术，对这两种多氧化分子的结构进行了阐明。AM18 在 9 μg/mL 时对白色念珠菌表现出抗真菌活性。
