Wayne Alan S, Shin-Kashiyama Erika, Sposto Richard, Gaynon Paul
a Children's Hospital of Los Angeles, USC Norris Comprehensive Cancer Center, Department of Pediatrics, Medicine, and Preventive Medicine , Keck School of Medicine, University of Southern California , Los Angeles , California , USA.
Pediatr Hematol Oncol. 2017 Sep-Oct;34(6-7):349-354. doi: 10.1080/08880018.2017.1377329. Epub 2017 Nov 9.
Despite great success in the development of curative therapies for pediatric hematologic malignancies, new approaches are needed to overcome resistance to treatment and to reduce associated side effects. The Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium is an early phase clinical trial group dedicated to developing innovative therapies for currently incurable pediatric leukemias and lymphomas ( https://tacl.chla.usc.edu/tacl/ ). In November of 2016, a TACL Investigator Meeting was held, the proceedings of which appear in this edition of Pediatric Hematology Oncology. This introductory article provides an overview of TACL and introduces the five-part proceedings.
尽管在儿童血液系统恶性肿瘤的治疗性疗法开发方面取得了巨大成功,但仍需要新的方法来克服治疗耐药性并减少相关副作用。儿童白血病和淋巴瘤治疗进展(TACL)联盟是一个早期临床试验小组,致力于为目前无法治愈的儿童白血病和淋巴瘤开发创新疗法(https://tacl.chla.usc.edu/tacl/)。2016年11月,召开了一次TACL研究者会议,其会议记录刊登在本期《儿科血液学与肿瘤学》上。这篇介绍性文章概述了TACL并介绍了由五部分组成的会议记录。