Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Curr Opin Struct Biol. 2018 Jun;50:49-57. doi: 10.1016/j.sbi.2017.09.005. Epub 2017 Nov 8.
This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.
本篇综述专注于近期的研究工作，这些工作已经开始确定蛋白质构象动态的特定功能作用，特别是蛋白质可以采样的构象景观如何在基于实验室的进化选择下进化。我们讨论了计算和生物物理化学方面的最新技术进展，这些进展为我们提供了剖析进化过程的新方法。最后，我们对构象动态和进化的新兴观点以及我们在合理设计构象动态方面面临的挑战提出了一些看法。
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