突破障碍：卢基病毒对宿主细胞的入侵。

Breaking the Barrier: Host Cell Invasion by Lujo Virus.

机构信息

Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

出版信息

Cell Host Microbe. 2017 Nov 8;22(5):583-585. doi: 10.1016/j.chom.2017.10.014.

DOI:10.1016/j.chom.2017.10.014

PMID:29120740

Abstract

Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV.

摘要

卢西病毒（LUJV）是一种沙粒病毒科病毒，于 2008 年出现，与一组人类严重出血热病例有关。在本期《细胞宿主与微生物》中，Raaben 等人（2017 年）确定神经纤毛蛋白（NRP）-2 为 LUJV 的细胞表面受体，四跨膜蛋白 CD63 为 LUJV 的细胞内进入因子。