Madhusudan Poorna, Wong Jean, Prasad Arun, Sadeghian Elena, Chung Frances F
Department of Anaesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Curr Opin Anaesthesiol. 2018 Feb;31(1):89-95. doi: 10.1097/ACO.0000000000000539.
There is a high prevalence of obstructive sleep apnea (OSA) in the surgical population, however, a significant proportion of patients are undiagnosed. The Society of Anesthesia and Sleep Medicine (SASM) has issued recent guidelines for preoperative assessment and preparation of patients with known or suspected OSA. The purpose of this review is to highlight key points in the new guidelines and explore the possibilities of different strategies in optimizing patients with OSA preoperatively.
Recent knowledge on phenotypes and endotypes has provided a better understanding of the disease and its underlying pathogenesis. Phenotypes refer to the predominant morphological characteristics of an individual whereas endotypes refer to the predominant underlying mechanism of the disease. Phenotypes and endotypes in OSA are heterogenous. Heterogeneity in the pathogenic mechanisms implies that opportunities other than the use of continuous positive airway pressure (CPAP) may exist to optimize or manage OSA patients preoperatively.
The prevalence of OSA in surgical patients is high. SASM has made recommendations in their published guidelines for the optimum preoperative preparation of patients with OSA. In the future, research may shift towards finding the underlying mechanism of OSA for targeted therapy.
手术患者中阻塞性睡眠呼吸暂停(OSA)的患病率很高,然而,相当一部分患者未被诊断出来。麻醉与睡眠医学协会(SASM)最近发布了关于已知或疑似OSA患者术前评估和准备的指南。本综述的目的是强调新指南中的要点,并探讨在术前优化OSA患者的不同策略的可能性。
最近关于表型和内型的知识使人们对该疾病及其潜在发病机制有了更好的理解。表型是指个体的主要形态特征,而内型是指疾病的主要潜在机制。OSA中的表型和内型是异质性的。致病机制的异质性意味着除了使用持续气道正压通气(CPAP)之外,可能还存在其他机会来术前优化或管理OSA患者。
手术患者中OSA的患病率很高。SASM在其发布的指南中对OSA患者的最佳术前准备提出了建议。未来,研究可能会转向寻找OSA的潜在机制以进行靶向治疗。