Yousef I M, Tuchweber B, Mignault D, Weber A
Department of Pharmacology, University of Montreal, Canada.
Am J Physiol. 1989 Jan;256(1 Pt 1):G62-6. doi: 10.1152/ajpgi.1989.256.1.G62.
The effect of combined infusion of sulfated cholic acid and nonsulfated cholic acid on bile formation was investigated. The data show that the secretion of sulfated cholic acid is slower and does not share the same transport mechanism(s) as nonsulfated cholic acid. Sulfated cholic acid significantly increased bile flow and reduced the secretion of biliary phospholipids, cholesterol, and protein associated with the secretion of exogenous nonsulfated cholic acid, only when they were infused in a ratio higher than 2:1 (sulfated:nonsulfated). Thus it is concluded that sulfated bile acids may protect the liver against the toxic effect of high concentration of bile acids. The relevance of these findings to human cholestasis remains to be determined because sulfated bile acids do not predominate in serum during cholestasis.
研究了硫酸化胆酸和非硫酸化胆酸联合输注对胆汁形成的影响。数据表明，硫酸化胆酸的分泌较慢，且与非硫酸化胆酸不共享相同的转运机制。仅当硫酸化胆酸和非硫酸化胆酸以高于2:1（硫酸化:非硫酸化）的比例输注时，硫酸化胆酸才会显著增加胆汁流量，并减少与外源性非硫酸化胆酸分泌相关的胆汁磷脂、胆固醇和蛋白质的分泌。因此得出结论，硫酸化胆汁酸可能保护肝脏免受高浓度胆汁酸的毒性作用。由于硫酸化胆汁酸在胆汁淤积期间在血清中并不占主导地位，这些发现与人类胆汁淤积的相关性仍有待确定。
