Yousef I M, Mignault D, Weber A M, Tuchweber B
Department of Pharmacology, University of Montreal, P.Q., Canada.
Digestion. 1990;45(1):40-51. doi: 10.1159/000200223.
This study investigated the influence of dehydrocholic acid (DHCA) infusion on the secretion of endogenous bile acids, and biliary lipids in rats in an attempt to explain the reduction of biliary lipid secretion associated with DHCA infusion. DHCA increased bile flow and the bile acids produced during the infusion were composed of three hydroxy-oxo metabolites (83-93%), and cholic acid (6-14%). Very little DHCA was secreted unchanged (less than 2%). The secretions of all the endogenous biliary bile acids were diminished within 30-60 min of infusion. DHCA furthermore reduced the secretion of exogenous cholic acid when co-infused with DHCA. Phospholipid secretion declined to an undetectable amount and cholesterol declined to 10% of the base value by the end of the infusion. The reduction of biliary lipid secretion during DHCA infusion was attributed to the diminished secretion of endogenous bile acids. These data show that DHCA infusion induces choleresis associated with reduced secretion of endogenous and/or exogenous biliary components.
本研究调查了脱氢胆酸（DHCA）输注对大鼠内源性胆汁酸分泌及胆汁脂质的影响，旨在解释与DHCA输注相关的胆汁脂质分泌减少的现象。DHCA增加胆汁流量，输注期间产生的胆汁酸由三种羟基 - 氧代代谢物（83 - 93%）和胆酸（6 - 14%）组成。极少的DHCA以未改变的形式分泌（少于2%）。在输注30 - 60分钟内，所有内源性胆汁酸的分泌均减少。此外，当与DHCA共同输注时，DHCA还降低了外源性胆酸的分泌。到输注结束时，磷脂分泌降至无法检测的水平，胆固醇降至基础值的10%。DHCA输注期间胆汁脂质分泌的减少归因于内源性胆汁酸分泌的减少。这些数据表明，DHCA输注诱导胆汁分泌增加，同时内源性和/或外源性胆汁成分的分泌减少。
