Liao Yu, Xu Lin, Lin Xiao, Hao Yuan Tao
Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.
Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China; Sun Yat-sen Global Health Institute, Institute of State Governance, Sun Yat-sen University, Guangzhou 510275, Guangdong, China.
Biomed Environ Sci. 2017 Oct;30(10):708-717. doi: 10.3967/bes2017.096.
To estimate the lung cancer burden that may be attributable to ambient fine particulate matter (PM2.5) pollution in Guangzhou city in China from 2005 to 2013.
The data regarding PM2.5 exposure were obtained from the 'Ambient air pollution exposure estimation for the Global Burden of Disease 2013' dataset at 0.1° ×0.1° spatial resolution. Disability-adjusted life years (DALYs) were estimated based on the information of mortality and incidence of lung cancer. Comparative risk analysis and integrated exposure-response function were used to estimate attributed disease burden.
The population-weighted average concentration of PM2.5 was increased by 34.6% between 1990 and 2013, from 38.37 μg/m3 to 51.31 μg/m3. The lung cancer DALYs in both men and women were increased by 36.2% from 2005 to 2013. The PM2.5 attributed lung cancer DALYs increased from 12105.0 (8181.0 for males and 3924.0 for females) in 2005 to 16489.3 (11291.7 for males and 5197.6 for females) in 2013. An average of 23.1% lung cancer burden was attributable to PM2.5 pollution in 2013.
PM2.5 has caused serious but under-appreciated public health burden in Guangzhou and the trend deteriorates. Effective strategies are needed to tackle this major public health problem.
估算2005年至2013年中国广州市因环境细颗粒物（PM2.5）污染导致的肺癌负担。
PM2.5暴露数据来自“2013年全球疾病负担的环境空气污染暴露估算”数据集，空间分辨率为0.1°×0.1°。基于肺癌死亡率和发病率信息估算伤残调整生命年（DALYs）。采用比较风险分析和综合暴露反应函数估算归因疾病负担。
1990年至2013年，PM2.5的人口加权平均浓度从38.37μg/m³增至51.31μg/m³，增幅为34.6%。2005年至2013年，男性和女性的肺癌DALYs均增加了36.2%。PM2.5归因的肺癌DALYs从2005年的12105.0（男性8181.0，女性3924.0）增至2013年的16489.3（男性11291.7，女性5197.6）。2013年，平均23.1%的肺癌负担可归因于PM2.5污染。
PM2.5在广州造成了严重但未得到充分重视的公共卫生负担，且这一趋势在恶化。需要采取有效策略来应对这一重大公共卫生问题。
