Strain George M
Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803-8420, USA.
Res Vet Sci. 2019 Jun;124:452-460. doi: 10.1016/j.rvsc.2017.10.008. Epub 2017 Oct 31.
The objective of the study was to assess the neurotoxicity, using electrodiagnostic tests, of hydramethylnon (Amdro, AC 217,300), an insecticide marketed for the treatment of red imported fire ants, cockroaches, and other insects. Animals were male Fisher 344 albino rats and Long-Evans hooded rats. Brainstem auditory, visual, and somatosensory evoked potentials (BAER, VEP, SEP) and electroencephalograms (EEG) were recorded from implanted screw electrodes before and at multiple time points through day 10 after a single oral dose of hydramethylnon (at 50% or 75% of the LD) plus vehicle, or vehicle alone. No evidence of nervous system toxicity was detected with either BAER, VEP, or SEP recordings. Spectral analysis of EEGs recorded over 7days demonstrated a time-limited increase in power at low frequencies and decrease at high frequencies, reflecting a sedative effect. A dose-dependent weight loss was observed. Single-exposure poisonings with AC 217,300 can be expected to produce anorexia and CNS depression, but not lethality.
本研究的目的是使用电诊断测试评估烯虫酯（Amdro、AC 217,300）的神经毒性，烯虫酯是一种用于防治红火蚁、蟑螂及其他昆虫的杀虫剂。实验动物为雄性费希尔344白化大鼠和长-伊文斯 hooded大鼠。在单次口服烯虫酯（剂量为半数致死量的50%或75%）加赋形剂或仅服赋形剂之前及之后直至第10天的多个时间点，通过植入的螺旋电极记录脑干听觉、视觉和躯体感觉诱发电位（BAER、VEP、SEP）以及脑电图（EEG）。BAER、VEP或SEP记录均未检测到神经系统毒性的证据。对记录7天的脑电图进行频谱分析表明，低频功率出现了限时增加，高频功率出现了降低，这反映出一种镇静作用。观察到了剂量依赖性体重减轻。预计单次接触AC 217,300会导致厌食和中枢神经系统抑制，但不会导致死亡。
