Louie A K, Lannon R A, Ketter T A
Department of Psychiatry, University of California San Francisco.
Am J Psychiatry. 1989 Jan;146(1):40-4. doi: 10.1176/ajp.146.1.40.
The authors describe 10 patients who developed panic attacks only after substantial cocaine use. The timing of the onset of symptoms, i.e., after 1-6 years of cocaine use, and the fact that only one patient had a first-degree relative with panic disorder were more suggestive of acquired than primary panic disorder. The patients' atypical symptoms and responses to medications may be explained in terms of limbic-neuronal hyperexcitability induced by cocaine through a kindling mechanism.
作者描述了10名仅在大量使用可卡因后出现惊恐发作的患者。症状发作的时间，即在使用可卡因1至6年后，以及只有一名患者有惊恐障碍的一级亲属这一事实，更表明是后天性而非原发性惊恐障碍。患者的非典型症状和对药物的反应可以用可卡因通过点燃机制诱导的边缘系统神经元过度兴奋来解释。
