Gentry James L, Carruthers David, Joshi Parag H, Maroules Christopher D, Ayers Colby R, de Lemos James A, Aagaard Philip, Hachamovitch Rory, Desai Milind Y, Roselli Eric E, Dunn Reginald E, Alexander Kezia, Lincoln Andrew E, Tucker Andrew M, Phelan Dermot M
From the Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, OH (J.L.G., P.A., R.H., M.Y.D., E.E.R., D.M.P.); Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (D.C., P.H.J., C.D.M., C.R.A., J.A.d.L.); Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD (P.H.J.); and MedStar Sports Medicine Research Center, Baltimore, MD (R.E.D., K.A., A.E.L., A.M.T.).
Circ Cardiovasc Imaging. 2017 Nov;10(11). doi: 10.1161/CIRCIMAGING.117.006852.
Ascending aortic dimensions are slightly larger in young competitive athletes compared with sedentary controls, but rarely >40 mm. Whether this finding translates to aortic enlargement in older, former athletes is unknown.
This cross-sectional study involved a sample of 206 former National Football League (NFL) athletes compared with 759 male subjects from the DHS-2 (Dallas Heart Study-2; mean age of 57.1 and 53.6 years, respectively, <0.0001; body surface area of 2.4 and 2.1 m, respectively, <0.0001). Midascending aortic dimensions were obtained from computed tomographic scans performed as part of a NFL screening protocol or as part of the DHS. Compared with a population-based control group, former NFL athletes had significantly larger ascending aortic diameters (38±5 versus 34±4 mm; <0.0001). A significantly higher proportion of former NFL athletes had an aorta of >40 mm (29.6% versus 8.6%; <0.0001). After adjusting for age, race, body surface area, systolic blood pressure, history of hypertension, current smoking, diabetes mellitus, and lipid profile, the former NFL athletes still had significantly larger ascending aortas (<0.0001). Former NFL athletes were twice as likely to have an aorta >40 mm after adjusting for the same parameters.
Ascending aortic dimensions were significantly larger in a sample of former NFL athletes after adjusting for their size, age, race, and cardiac risk factors. Whether this translates to an increased risk is unknown and requires further evaluation.
与久坐不动的对照组相比，年轻的竞技运动员升主动脉尺寸略大，但很少超过40毫米。这一发现是否适用于年龄较大的前运动员的主动脉扩张尚不清楚。
这项横断面研究纳入了206名前美国国家橄榄球联盟（NFL）运动员的样本，并与来自达拉斯心脏研究-2（DHS-2）的759名男性受试者进行比较（平均年龄分别为57.1岁和53.6岁，P<0.0001；体表面积分别为2.4平方米和2.1平方米，P<0.0001）。升主动脉中部尺寸通过作为NFL筛查方案一部分或DHS一部分进行的计算机断层扫描获得。与基于人群的对照组相比，前NFL运动员的升主动脉直径明显更大（38±5毫米对34±4毫米；P<0.0001）。前NFL运动员中主动脉直径>40毫米的比例明显更高（29.6%对8.6%；P<0.0001）。在调整年龄、种族、体表面积、收缩压、高血压病史、当前吸烟、糖尿病和血脂水平后，前NFL运动员的升主动脉仍然明显更大（P<0.0001）。在调整相同参数后！前NFL运动员主动脉直径>40毫米的可能性是对照组的两倍。
在调整了体型、年龄、种族和心脏危险因素后，前NFL运动员样本中的升主动脉尺寸明显更大。这是否会转化为风险增加尚不清楚，需要进一步评估。
