Wolak Arik, Gransar Heidi, Thomson Louise E J, Friedman John D, Hachamovitch Rory, Gutstein Ariel, Shaw Leslee J, Polk Donna, Wong Nathan D, Saouaf Rola, Hayes Sean W, Rozanski Alan, Slomka Piotr J, Germano Guido, Berman Daniel S
Departments of Imaging, CSMC Burns & Allen Research Institute, Cedars-Sinai Medical Center, University of California at Los Angeles, USA.
JACC Cardiovasc Imaging. 2008 Mar;1(2):200-9. doi: 10.1016/j.jcmg.2007.11.005.
To determine normal limits for ascending and descending thoracic aorta diameters in a large population of asymptomatic, low-risk adult subjects.
Assessment of aortic size is possible from gated noncontrast computed tomography (CT) scans obtained for coronary calcium measurements. However, normal limits for aortic size by these studies have yet to be defined.
In 4,039 adult patients undergoing coronary artery calcium (CAC) scanning, systematic measurements of the ascending and descending thoracic aorta diameters were made at the level of the pulmonary artery bifurcation. Multiple linear regression analysis was used to detect risk factors independently associated with ascending and descending thoracic aorta diameter and exclude subjects with these parameters from the final analysis. The final analysis groups for ascending and descending thoracic aorta included 2,952 and 1,931 subjects, respectively. Subjects were then regrouped by gender, age, and body surface area (BSA) for ascending and descending aorta, separately, and for each group, the mean, standard deviation, and upper normal limit were calculated for aortic diameter as well as for the calculated cross-sectional aortic area. Also, linear regression models were used to create BSA versus aortic diameter nomograms by age groups, and a formula for calculating predicted aortic size by age, gender, and BSA was created.
Age, BSA, gender, and hypertension were directly associated with thoracic aorta dimensions. Additionally, diabetes was associated with ascending aorta diameter, and smoking was associated with descending aorta diameter. The mean diameters for the final analysis group were 33 +/- 4 mm for the ascending and 24 +/- 3 mm for the descending thoracic aorta, respectively. The corresponding upper limits of normal diameters were 41 and 30 mm, respectively.
Normal limits of ascending and descending aortic dimensions by noncontrast gated cardiac CT have been defined by age, gender, and BSA in a large, low-risk population of subjects undergoing CAC scanning.
确定大量无症状、低风险成年受试者胸主动脉升段和降段直径的正常范围。
通过用于冠状动脉钙化测量的门控非增强计算机断层扫描（CT）可以评估主动脉大小。然而，这些研究中主动脉大小的正常范围尚未确定。
在4039例接受冠状动脉钙化（CAC）扫描的成年患者中，在肺动脉分叉水平对胸主动脉升段和降段直径进行系统测量。采用多元线性回归分析来检测与胸主动脉升段和降段直径独立相关的危险因素，并在最终分析中排除具有这些参数的受试者。胸主动脉升段和降段的最终分析组分别包括2952例和1931例受试者。然后，根据性别、年龄和体表面积（BSA）对胸主动脉升段和降段分别进行重新分组，并计算每组主动脉直径以及计算得到的主动脉横截面积的平均值、标准差和正常上限。此外，使用线性回归模型按年龄组创建BSA与主动脉直径的列线图，并创建一个根据年龄、性别和BSA计算预测主动脉大小的公式。
年龄、BSA、性别和高血压与胸主动脉尺寸直接相关。此外，糖尿病与胸主动脉升段直径相关，吸烟与胸主动脉降段直径相关。最终分析组的平均直径分别为胸主动脉升段33±4mm和胸主动脉降段24±3mm。相应的正常直径上限分别为41mm和30mm。
在接受CAC扫描的大量低风险受试者中，已根据年龄、性别和BSA确定了门控非增强心脏CT测量的胸主动脉升段和降段尺寸的正常范围。
