基因分型自然杀伤免疫检查点以发现反应的生物标志物。
Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response.
机构信息
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
出版信息
Clin Cancer Res. 2018 Jan 1;24(1):3-5. doi: 10.1158/1078-0432.CCR-17-2884. Epub 2017 Nov 9.
Abstract
Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural killer cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome. .
摘要
免疫检查点是近十年来免疫治疗的重点。杀伤细胞免疫球蛋白样受体（KIR）及其同源人类白细胞抗原（HLA）I 类配体作为检查点进化，以确保自然杀伤细胞的自身耐受性。KIR 和 HLA 遗传特征均是免疫治疗结果的潜在生物标志物。
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本文引用的文献
1
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Clin Cancer Res. 2018 Jan 1;24(1):189-196. doi: 10.1158/1078-0432.CCR-17-1767. Epub 2017 Oct 2.
2
KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.
J Clin Oncol. 2017 Jul 10;35(20):2268-2278. doi: 10.1200/JCO.2016.70.7059. Epub 2017 May 18.
3
KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.
J Clin Oncol. 2016 Jul 20;34(21):2443-51. doi: 10.1200/JCO.2015.64.9558. Epub 2016 Apr 11.
4
NK cells and cancer: you can teach innate cells new tricks.
Nat Rev Cancer. 2016 Jan;16(1):7-19. doi: 10.1038/nrc.2015.5.
5
Neuroblastoma: developmental biology, cancer genomics and immunotherapy.
Nat Rev Cancer. 2013 Jun;13(6):397-411. doi: 10.1038/nrc3526.
6
Murine anti-GD2 monoclonal antibody 3F8 combined with granulocyte-macrophage colony-stimulating factor and 13-cis-retinoic acid in high-risk patients with stage 4 neuroblastoma in first remission.
J Clin Oncol. 2012 Sep 10;30(26):3264-70. doi: 10.1200/JCO.2011.41.3807. Epub 2012 Aug 6.
7
Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.
Cancer Res. 2010 Dec 1;70(23):9554-61. doi: 10.1158/0008-5472.CAN-10-2211. Epub 2010 Oct 8.
8
Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.
N Engl J Med. 2010 Sep 30;363(14):1324-34. doi: 10.1056/NEJMoa0911123.
9
Differentiation induced by physiological and pharmacological stimuli leads to increased antigenicity of human neuroblastoma cells.
Cell Res. 2008 Mar;18(3):398-411. doi: 10.1038/cr.2008.27.
10
Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications.
Oncogene. 2005 Jul 7;24(29):4634-44. doi: 10.1038/sj.onc.1208594.
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