Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, USA.
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
J Epidemiol Community Health. 2018 Jan;72(1):13-20. doi: 10.1136/jech-2017-209903. Epub 2017 Nov 9.
Few studies have prospectively evaluated the association of leisure-time physical activity (LTPA) with mortality in Asians, who are more susceptible to insulin resistance than their Caucasian counterparts.
Data from two large prospective cohort studies conducted in Shanghai were evaluated. After excluding participants who had a history of cancer, coronary heart disease or stroke at baseline, or who died within the first 3 years after study enrolment, 53 839 men and 66 888 women, followed for an average of 9.2 and 14.7 years, respectively, remained for the study.
Compared with those who reported no exercise, a reduction in mortality with an HR of 0.86 (95% CI 0.80 to 0.93) was observed in those who regularly engage in moderate-intensity LTPA, even those who reported an LTPA level lower than the minimum amount recommended by the current physical activity guidelines (150 min or 7.5 metabolic equivalent hours per week). The association between moderate-intensity exercise and mortality followed a dose-response pattern until the amount of LTPA reached 3-5 times the recommended minimum level. A similar pattern of association was observed for cause-specific mortality due to cardiovascular disease (CVD), cancer or other causes.
Regular participation in moderate-intensity LTPA was associated with reduced mortality, particularly CVD mortality, even when the LTPA was below the minimum level recommended by current guidelines. Increasing the amount of moderate-intensity LTPA was associated with further risk reduction up to a potential threshold of 3-5 times the recommended minimum.
很少有研究前瞻性地评估亚洲人休闲时间体力活动（LTPA）与死亡率之间的关系，亚洲人比白种人更容易出现胰岛素抵抗。
评估了两项在上海进行的大型前瞻性队列研究的数据。在排除了基线时有癌症、冠心病或中风病史或在研究入组后 3 年内死亡的参与者后，分别有 53839 名男性和 66888 名女性被纳入研究，平均随访时间分别为 9.2 年和 14.7 年。
与不运动的人相比，经常进行中等强度 LTPA 的人死亡率降低，HR 为 0.86（95%CI 0.80 至 0.93），即使是那些报告的 LTPA 水平低于当前体力活动指南推荐的最低量（150 分钟或每周 7.5 代谢当量小时）。中等强度运动与死亡率之间的关联呈剂量反应模式，直到 LTPA 量达到推荐最低水平的 3-5 倍。心血管疾病（CVD）、癌症或其他原因导致的特定原因死亡率也存在类似的关联模式。
定期进行中等强度的 LTPA 与降低死亡率相关，尤其是 CVD 死亡率，即使 LTPA 低于当前指南推荐的最低水平。增加中等强度 LTPA 的量与进一步降低风险相关，最高可达推荐最低水平的 3-5 倍。
