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α-乙烯基赖氨酸和α-乙烯基精氨酸是其同源脱羧酶的时间依赖性抑制剂。

α-VINYLLYSINE AND α-VINYLARGININE ARE TIME-DEPENDENT INHIBITORS OF THEIR COGNATE DECARBOXYLASES.

作者信息

Berkowitz David B, Jahng Wan-Jin, Pedersen Michelle L

机构信息

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304.

出版信息

Bioorg Med Chem Lett. 1996 Sep 17;6(18):2151-2156. doi: 10.1016/0960-894X(96)00366-6.

DOI:10.1016/0960-894X(96)00366-6
PMID:29123334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5675568/
Abstract

(±)-α-Vinyllysine and (±)-α-vinylarginine display time-dependent inhibition of L-lysine decarboxylase from , and L-arginine decarboxylase from , respectively. A complete Kitz-Wilson analysis has been performed using a modification of the Palcic continuous UV assay for decarboxylase activity.

摘要

（±）-α-乙烯基赖氨酸和（±）-α-乙烯基精氨酸分别对来自[具体来源1]的L-赖氨酸脱羧酶和来自[具体来源2]的L-精氨酸脱羧酶表现出时间依赖性抑制作用。已使用Palcic连续紫外法测定脱羧酶活性的改进方法进行了完整的Kitz-Wilson分析。

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本文引用的文献

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A Convenient Synthesis of L-α-Vinylglycine from L-Homoserine Lactone.由L-高丝氨酸内酯便捷合成L-α-乙烯基甘氨酸
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Free α-Oxiranyl Amino Acids.游离α-环氧乙烷基氨基酸。
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Synthesis of Higher α-Chlorovinyl and α-Bromovinyl Amino Acids: The Amino Protecting Group Determines the Reaction Course.高级α-氯代乙烯基和α-溴代乙烯基氨基酸的合成：氨基保护基团决定反应进程。
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alpha-Ethynyl and alpha-vinyl analogues of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase.鸟氨酸的α-乙炔基和α-乙烯基类似物作为哺乳动物鸟氨酸脱羧酶的酶激活抑制剂。
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Cysteinesulfinate metabolism. altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate.半胱氨酸亚磺酸盐代谢。给予β-亚甲基天冬氨酸后，转氨作用和脱羧作用之间的分配发生改变。
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Replacement of natural polyamines by cadaverine and its aminopropyl derivatives in Ehrlich ascites carcinoma cells.用尸胺及其氨丙基衍生物替代艾氏腹水癌细胞中的天然多胺
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DL-alpha-(Difluoromethyl)arginine: a potent enzyme-activated irreversible inhibitor of bacterial decarboxylases.DL-α-（二氟甲基）精氨酸：一种强效的酶激活不可逆细菌脱羧酶抑制剂。
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Selective inhibition of alanine aminotransferase and aspartate aminotransferase in rat hepatocytes.大鼠肝细胞中丙氨酸氨基转移酶和天冬氨酸氨基转移酶的选择性抑制
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