Bruni G, Dal Pra P, Segre G
Int J Tissue React. 1984;6(6):463-9.
Several non-steroidal antiinflammatory drugs (NSAID) were shown to inhibit to various extents the decarboxylases of ornithine, lysine, histidine, arginine, and tyrosine. The most sensitive enzyme was ornithine decarboxylase, for which piroxicam, benoxaprofen and aminophenazone showed an IC50 of 0.007 mM; ibuprofen competitively inhibits the lysine decarboxylase. The most effective NSAID's in inhibiting histidine decarboxylase were mefenamic acid, ibuprofen and flufenamic acid. Arginine and tyrosine decarboxylase were inhibited by NSAID's only at high concentrations. None of the decarboxylase inhibitions were reversed by pyridoxal phosphate. Subplantar injection of the 5 amines formed by these aminoacid decarboxylases elicited a paw oedema in rat which was not antagonized by the various NSAID's. Some of the NSAID's stimulated all the decarboxylases and did not antagonize the carrageenin-induced paw oedema. With one exception, all the NSAID's tested in vivo inhibited the elimination of 14CO2 from labeled ornithine and lysine. The inhibition of certain aminoacid decarboxylases, particularly ornithine and lysine decarboxylase, appears to be a noteworthy mechanism of action for certain NSAID's.
几种非甾体抗炎药（NSAID）已被证明在不同程度上抑制鸟氨酸、赖氨酸、组氨酸、精氨酸和酪氨酸的脱羧酶。最敏感的酶是鸟氨酸脱羧酶，吡罗昔康、苯恶洛芬和氨基苯酮对其显示出0.007 mM的半数抑制浓度（IC50）；布洛芬竞争性抑制赖氨酸脱羧酶。抑制组氨酸脱羧酶最有效的NSAID是甲芬那酸、布洛芬和氟芬那酸。精氨酸和酪氨酸脱羧酶仅在高浓度下被NSAID抑制。这些脱羧酶的抑制作用均未被磷酸吡哆醛逆转。足底注射由这些氨基酸脱羧酶形成的5种胺会引起大鼠爪肿胀，而各种NSAID并未拮抗这种肿胀。一些NSAID刺激了所有脱羧酶，并且未拮抗角叉菜胶诱导的爪肿胀。除了一个例外，所有在体内测试的NSAID都抑制了标记的鸟氨酸和赖氨酸中14CO2的消除。抑制某些氨基酸脱羧酶，特别是鸟氨酸和赖氨酸脱羧酶，似乎是某些NSAID值得注意的作用机制。
