Patel Jaivika Govindbhai, Bhise Anjali R
Department of Cardiopulmonary Physiotherapy, Civil Hospital, Government Physiotherapy College, Government Spine Institute, Ahmedabad, Gujarat, India.
Indian J Palliat Care. 2017 Oct-Dec;23(4):355-361. doi: 10.4103/IJPC.IJPC_65_17.
Fatigue is the most common side effect of cancer treatment with chemotherapy and/or radiation therapy, selected biologic response modifiers. The main purpose of this study is to evaluate the effects of aerobic exercise on cancer-related fatigue in patients of the solid tumor after chemotherapy and radiotherapy.
After screening for cancer-related fatigue, 34 patients fulfilled the inclusive criteria and were assigned into two groups ( = 17 recruited in the intervention group and = 17 in control group). The intervention group received aerobic exercise program which included treadmill walking with low to moderate intensity (50%-70% of maximum heart rate), for 20-40 min/day for 5 days/week. Control group were taught stretching exercises of hamstrings, gastrocnemius, and soleus (to be done at home) and were encouraged to remain active. Outcome measures such as brief fatigue inventory (BFI), 6-min walk test, and functional assessment of cancer therapy-general (FACT-G) were taken at baseline and after 6-weeks.
The data were analyzed using the Wilcoxon matched-pairs signed rank test for within group and Mann-Whitney U-test for between group comparisons. The results of this study showed that there was a significant reduction in cancer-related fatigue BFI score ( < 0.0001,), also there was significant improvement in the physical performance as in 6-min walk distance ( < 0.0001) and quality of life, FACT-G score ( = 0.0001).
Aerobic exercise for 6 weeks has beneficial effects on cancer-related fatigue in patients with solid tumor after chemotherapy and/or radiotherapy.
疲劳是癌症化疗和/或放疗以及某些生物反应调节剂治疗中最常见的副作用。本研究的主要目的是评估有氧运动对实体瘤患者化疗和放疗后癌症相关疲劳的影响。
在筛查癌症相关疲劳后，34名患者符合纳入标准，被分为两组（干预组17例，对照组17例）。干预组接受有氧运动计划，包括以低至中等强度（最大心率的50%-70%）在跑步机上行走，每天20-40分钟，每周5天。对照组接受腘绳肌、腓肠肌和比目鱼肌拉伸运动的指导（在家中进行），并鼓励保持活跃。在基线和6周后采用简短疲劳量表（BFI）、6分钟步行试验和癌症治疗功能评估通用量表（FACT-G）等结果指标。
采用Wilcoxon配对符号秩检验进行组内分析，采用Mann-Whitney U检验进行组间比较。本研究结果表明，癌症相关疲劳BFI评分显著降低（P<0.0001），6分钟步行距离所反映的身体表现（P<0.0001）和生活质量FACT-G评分（P = 0.0001）也有显著改善。
有氧运动6周对实体瘤患者化疗和/或放疗后的癌症相关疲劳有有益影响。
