Kuehn Mareike, Wypyrsczyk Lena, Stoessel Sandra, Neu Marie A, Ploch Lisa, Dreismickenbecker Elias, Simon Perikles, Faber Joerg
Center for Pediatric and Adolescent Medicine, Department of Pediatric Hematology/Oncology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Institute of Sport Science, Department Sport Medicine, Rehabilitation and Disease Prevention, Johannes Gutenberg University, 55128 Mainz, Germany.
Children (Basel). 2023 Mar 17;10(3):572. doi: 10.3390/children10030572.
Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in paediatric oncology. Based on previous studies, physical activity interventions are considered to be effective in reducing CRF in adult cancer patients.
The aim of this systematic review is to investigate whether physical activity interventions can reduce CRF in paediatric patients undergoing cancer treatment.
A systematic literature search was conducted in PubMed and Sport-Discus in October 2021 to identify intervention studies examining the effects of physical activity on CRF in cancer patients ≤ 21 years of age. Their methodological quality was assessed using the JBI Critical Appraisal Tool.
A total of 20 studies (seven randomized-controlled, six quasi-experimental and seven single-arm intervention trials) were included in the review. Nine studies reported significant positive effects of physical activity interventions on CRF in group comparison or within groups. Eleven trials reported no significant changes in CRF.
Physical activity as a therapeutic intervention in paediatric oncology may have the potential to reduce CRF in childhood cancer patients undergoing cancer treatment. Further high-quality studies with large samples are needed to verify these results and to assess the interdependence of dose and response of physical activity interventions.
癌症相关疲劳（CRF）是儿科肿瘤学中最常见且令人痛苦的症状之一。根据以往研究，体育活动干预被认为对减轻成年癌症患者的CRF有效。
本系统评价的目的是调查体育活动干预是否能减轻接受癌症治疗的儿科患者的CRF。
2021年10月在PubMed和Sport-Discus中进行了系统的文献检索，以确定研究体育活动对21岁及以下癌症患者CRF影响的干预研究。使用JBI批判性评价工具评估其方法学质量。
本评价共纳入20项研究（7项随机对照试验、6项准实验和7项单臂干预试验）。9项研究报告了体育活动干预在组间比较或组内对CRF有显著的积极影响。11项试验报告CRF无显著变化。
体育活动作为儿科肿瘤学的一种治疗干预措施，可能有潜力减轻接受癌症治疗的儿童癌症患者的CRF。需要进一步开展大样本的高质量研究来验证这些结果，并评估体育活动干预的剂量与反应之间的相互关系。
