Xie Jing, Deng Wuquan
Department of Endocrinology and Nephrology, Chongqing Emergency Medical Center, the Fourth People's Hospital of Chongqing, Chongqing, China.
Neuropsychiatr Dis Treat. 2017 Oct 24;13:2681-2690. doi: 10.2147/NDT.S116465. eCollection 2017.
The efficacy of psychosocial intervention has been proven in treatment of diabetic patients with depression in some studies. This meta-analysis was conducted to explore the efficacy as well as additional effects of this method during diabetic management in patients with type 2 diabetes mellitus (T2DM) and comorbid depression.
Electronic databases were searched from March 2000 to March 2017 for randomized controlled trials (RCTs) studying the effects of psychosocial intervention on T2DM patients with depression. There was no language limitation. Outcome measurements were symptoms of depression and anxiety, as well as glycemic control. A random effects model was conducted.
In total, 31 RCTs composed of 2,616 patients were eligible for this analysis. The psychosocial intervention was effective for depression symptoms with pooled standardized mean difference (SMD) of -1.50 (95% CI =-1.83, -1.18) and anxiety symptoms with SMD of -1.18 (95% CI =-1.50, -0.85). Meanwhile, the additional effects indicated a better improvement of glycemic control, including the fasting blood-glucose with SMD of -0.93 (95% CI =-1.15, -0.71), 2-hour postprandial plasma glucose with SMD of -0.84 (95% CI =-1.13, -0.56), and hemoglobin A1c with SMD of -0.81 (95% CI =-1.10, -0.53).
These results demonstrate that the psychosocial intervention is very effective in treating T2DM patients with depression.
一些研究已证实心理社会干预在治疗伴有抑郁症的糖尿病患者中具有疗效。本荟萃分析旨在探讨该方法在2型糖尿病（T2DM）合并抑郁症患者的糖尿病管理过程中的疗效及附加效果。
检索2000年3月至2017年3月的电子数据库，查找研究心理社会干预对伴有抑郁症的T2DM患者影响的随机对照试验（RCT）。无语言限制。结局指标为抑郁和焦虑症状以及血糖控制情况。采用随机效应模型。
共有31项RCT（包含2616例患者）符合本分析要求。心理社会干预对抑郁症状有效，合并标准化均数差（SMD）为-1.50（95%CI=-1.83，-1.18），对焦虑症状有效，SMD为-1.18（95%CI=-1.50，-0.85）。同时，附加效果表明血糖控制有更好改善，包括空腹血糖SMD为-0.93（95%CI=-1.15，-0.71），餐后2小时血糖SMD为-0.84（95%CI=-1.13，-0.56），糖化血红蛋白SMD为-0.81（95%CI=-1.10，-0.53）。
这些结果表明心理社会干预在治疗伴有抑郁症的T2DM患者中非常有效。
