Cheng Xi, Wang Huibin, Zhang Xiuchun, Zhao Shanshan, Zhou Zhike, Mu Xiaopeng, Zhao Chuansheng, Teng Weiyu
Neurology, The First Hospital of China Medical University, Shenyang, China.
Geriatrics, The First Hospital of China Medical University, Shenyang, China.
Front Neurosci. 2017 Oct 24;11:590. doi: 10.3389/fnins.2017.00590. eCollection 2017.
Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) as well as exerting a role in cancer. SDF-1 activates two G protein-coupled receptors, CXCR4 and CXCR7; these are expressed in both developing and mature CNSs and participate in multiple physiological and pathological events, e.g., inflammatory response, neurogenesis, angiogenesis, hematopoiesis, cancer metastasis, and HIV infection. After an ischemic stroke, SDF-1 levels robustly increase in the penumbra regions and participate in adult neural functional repair. Here we will review recent findings about SDF-1 and its receptor, analyse their functions in neurogeneration after brain ischemic injury: i.e., how the system promotes the proliferation, differentiation and migration of neural precursor cells and mediates axonal elongation and branching.
基质细胞衍生因子-1是一种由骨髓基质细胞系产生的趋化因子。它被认为是免疫和中枢神经系统中的关键因子，同时在癌症中也发挥作用。SDF-1激活两种G蛋白偶联受体，即CXCR4和CXCR7；它们在发育中的和成熟的中枢神经系统中均有表达，并参与多种生理和病理过程，例如炎症反应、神经发生、血管生成、造血、癌症转移和HIV感染。缺血性中风后，SDF-1水平在半暗带区域显著升高，并参与成年神经功能修复。在此，我们将综述关于SDF-1及其受体的最新研究发现，分析它们在脑缺血损伤后神经发生中的作用：即该系统如何促进神经前体细胞的增殖、分化和迁移，并介导轴突的伸长和分支。
