Rae John, Misselbrook Katie
Department of Anaesthesia, Ninewells Hospital, Dundee, UK.
J Intensive Care Soc. 2017 Nov;18(4):329-333. doi: 10.1177/1751143717698978. Epub 2017 Mar 14.
Lemierre's syndrome is a rare complication of acute pharyngitis characterised by septicaemia with infective thrombophlebitis of the internal jugular vein, most commonly due to . It characteristically affects healthy young adults causing persistent pyrexia and systemic sepsis presenting several days after an initial pharyngitis. Septic emboli seed via the bloodstream to distant sites including the lung, joints, skin, liver, spleen and brain. Prolonged antimicrobial therapy is required and admission to intensive care common. This once rare condition is increasing in incidence but awareness amongst clinicians is low. We present a classic case in a young man who developed multi-organ failure requiring intensive care support and describe the epidemiology, pathophysiology, microbiology, clinical features and management of the disease.
勒米尔综合征是急性咽炎的一种罕见并发症，其特征为败血症伴颈内静脉感染性血栓性静脉炎，最常见的病因是……。它典型地影响健康的年轻人，在最初的咽炎发作几天后导致持续发热和全身败血症。感染性栓子通过血流播散至远处部位，包括肺、关节、皮肤、肝脏、脾脏和大脑。需要长期抗菌治疗，通常需入住重症监护病房。这种曾经罕见的疾病发病率正在上升，但临床医生对此的认识较低。我们报告一例年轻男性发生多器官功能衰竭需要重症监护支持的典型病例，并描述该疾病的流行病学、病理生理学、微生物学、临床特征及治疗。
