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本文引用的文献

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induces gut intraepithelial CD4CD8αα T cells.诱导肠道上皮内CD4CD8αα T细胞。
Science. 2017 Aug 25;357(6353):806-810. doi: 10.1126/science.aah5825. Epub 2017 Aug 3.
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Microbiome, metabolites and host immunity.微生物组、代谢物与宿主免疫。
Curr Opin Microbiol. 2017 Feb;35:8-15. doi: 10.1016/j.mib.2016.10.003. Epub 2016 Nov 22.
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Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease.新发克罗恩病中肠道微生物群-宿主线粒体串扰的改变。
Nat Commun. 2016 Nov 23;7:13419. doi: 10.1038/ncomms13419.
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Early Changes in Microbial Community Structure Are Associated with Sustained Remission After Nutritional Treatment of Pediatric Crohn's Disease.儿童克罗恩病营养治疗后微生物群落结构的早期变化与持续缓解相关。
Inflamm Bowel Dis. 2016 Dec;22(12):2853-2862. doi: 10.1097/MIB.0000000000000956.
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Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.宿主遗传学与肠道微生物群在炎症性肠病发病及临床表现中的相互作用
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Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.抗生素介导的肠道微生物组扰动加速了小鼠 1 型糖尿病的发展。
Nat Microbiol. 2016 Aug 22;1(11):16140. doi: 10.1038/nmicrobiol.2016.140.
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Striking a Balance with Help from our Little Friends - How the Gut Microbiota Contributes to Immune Homeostasis.在我们的小伙伴的帮助下实现平衡——肠道微生物群如何促进免疫稳态。
Yale J Biol Med. 2016 Sep 30;89(3):389-395. eCollection 2016 Sep.
8
The Role of the Intestinal Microbiome in Type 1 Diabetes Pathogenesis.肠道微生物群在1型糖尿病发病机制中的作用
Curr Diab Rep. 2016 Oct;16(10):89. doi: 10.1007/s11892-016-0781-z.
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On the pathogenesis of insulin-dependent diabetes mellitus: the role of microbiota.关于胰岛素依赖型糖尿病的发病机制：微生物群的作用。
Immunol Res. 2017 Feb;65(1):242-256. doi: 10.1007/s12026-016-8832-8.
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Anti-inflammatory effect of exclusive enteral nutrition in patients with juvenile idiopathic arthritis.全肠内营养对幼年特发性关节炎患者的抗炎作用。
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肠内营养专方诱导儿科克罗恩病缓解：基于肠道菌群的调节作用

Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota.

机构信息

Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266071, China.

出版信息

Biomed Res Int. 2017;2017:8102589. doi: 10.1155/2017/8102589. Epub 2017 Oct 16.

DOI:10.1155/2017/8102589
PMID:29124070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5662815/
Abstract

Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent studies have demonstrated that modulation of the gut microbiota plays a major role in EEN-induced remission. Variations of microbial components, which directly influence the diversity and metabolic functions of the gut microbiota, are closely associated with the immunological conditions of the gut and the susceptibility to diseases. The reduction of proinflammatory microbial components and harmful microbial metabolites after EEN treatment greatly decreases the inflammatory injuries of the gut.

摘要

肠内营养（EEN）在治疗小儿克罗恩病（CD）方面已被证明是有效且安全的。EEN 诱导小儿 CD 缓解可能通过三种途径：（1）直接抗炎作用，（2）改善上皮屏障功能，和（3）调节肠道微生物群。最近的研究表明，调节肠道微生物群在 EEN 诱导的缓解中起着主要作用。微生物成分的变化，直接影响肠道微生物群的多样性和代谢功能，与肠道的免疫状态和疾病易感性密切相关。EEN 治疗后促炎微生物成分和有害微生物代谢物的减少大大降低了肠道的炎症损伤。