肠内营养专方诱导儿科克罗恩病缓解：基于肠道菌群的调节作用
Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota.
机构信息
Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China.
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266071, China.
出版信息
Biomed Res Int. 2017;2017:8102589. doi: 10.1155/2017/8102589. Epub 2017 Oct 16.
Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent studies have demonstrated that modulation of the gut microbiota plays a major role in EEN-induced remission. Variations of microbial components, which directly influence the diversity and metabolic functions of the gut microbiota, are closely associated with the immunological conditions of the gut and the susceptibility to diseases. The reduction of proinflammatory microbial components and harmful microbial metabolites after EEN treatment greatly decreases the inflammatory injuries of the gut.
肠内营养（EEN）在治疗小儿克罗恩病（CD）方面已被证明是有效且安全的。EEN 诱导小儿 CD 缓解可能通过三种途径：（1）直接抗炎作用，（2）改善上皮屏障功能，和（3）调节肠道微生物群。最近的研究表明，调节肠道微生物群在 EEN 诱导的缓解中起着主要作用。微生物成分的变化，直接影响肠道微生物群的多样性和代谢功能，与肠道的免疫状态和疾病易感性密切相关。EEN 治疗后促炎微生物成分和有害微生物代谢物的减少大大降低了肠道的炎症损伤。
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