一种与血管内皮细胞形成一氧化氮有关的新型瓜氨酸形成酶。
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.
作者信息
Palmer R M, Moncada S
机构信息
Wellcome Research Laboratories, Langley Court, Beckenham, U.K.
出版信息
Biochem Biophys Res Commun. 1989 Jan 16;158(1):348-52. doi: 10.1016/s0006-291x(89)80219-0.
PMID:2912454
Abstract
An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.
摘要
猪血管内皮细胞匀浆中的一种酶可由L-精氨酸生成L-瓜氨酸。这种酶是可溶性的且依赖于NADPH。此外，该酶受到NG-单甲基-L-精氨酸的抑制，这表明它参与血管内皮细胞一氧化氮的形成。
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