Kislal Sezen, Blizard David A
Department of Biobehavioral Health, Pennsylvania State University, State College, USA.
School of Medicine, Neurosurgery, Stanford University, Palo Alto, CA, 94304, USA.
Learn Behav. 2018 Jun;46(2):198-212. doi: 10.3758/s13420-017-0303-0.
We compared the rate of acquisition and strength of retention of conditioned context aversion (CCA) with conditioned taste aversion (CTA) using pigmented, genetically heterogeneous mice (derived from Large and Small strains). Extending previous findings, in Experiment 1, mice accustomed to drinking from large glass bottles in the colony room learned to avoid graduated tubes after a single conditioning trial when drinking from these novel tubes was paired with injections of LiCl. The results also showed that CCA could be developed even when there was a 30-minute delay between conditioned stimulus and unconditioned stimulus. Retention of the aversion lasted for 4 weeks in both Immediate and Delay groups. Studies of conditioned saccharin aversion were conducted in Experiment 2. CTA acquisition was very similar to that observed in CCA and duration of aversion retention was similar in the CCA and CTA Delay groups, although at least 2 weeks longer in the Immediate group. Thus, CCA acquisition and retention characteristics are closer to those seen for CTA than has previously been reported. In Experiment 3, we examined whether albino mice (which are known to have weaker visual abilities compared to pigmented mice) would develop CCA comparable to those of pigmented mice. The development of conditioned aversion and its duration of retention was similar in albinos and pigmented mice. Nonspecific aversion emerged as an important contributor to strength of aversion during retention trials in both CCA and CTA paradigms with pigmented (but not albino) mice and deserves additional scrutiny in this field of inquiry.
我们使用有色的、基因异质的小鼠（源自大体型和小体型品系），比较了条件性情境厌恶（CCA）与条件性味觉厌恶（CTA）的习得率和记忆强度。扩展先前的研究结果，在实验1中，习惯于在饲养室从大玻璃瓶饮水的小鼠，当从这些新型试管饮水与注射氯化锂配对时，经过单次条件化试验后学会避开刻度试管。结果还表明，即使条件刺激和非条件刺激之间有30分钟的延迟，也能形成CCA。即时组和延迟组的厌恶记忆都持续了4周。在实验2中进行了条件性糖精厌恶的研究。CTA的习得与CCA中观察到的非常相似，并且在CCA和CTA延迟组中厌恶记忆的持续时间相似，尽管即时组至少长2周。因此，CCA的习得和记忆特征比以前报道的更接近CTA。在实验3中，我们研究了白化小鼠（已知其视觉能力比有色小鼠弱）是否会形成与有色小鼠相当的CCA。白化小鼠和有色小鼠的条件性厌恶的形成及其记忆持续时间相似。在有色（但不是白化）小鼠的CCA和CTA范式的记忆试验中，非特异性厌恶成为厌恶强度的一个重要因素，在这个研究领域值得进一步研究。
