无线电电不对称输送技术调节神经退行性变小鼠模型中的神经炎症。
Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration.
机构信息
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
CNR Institute for Microelectronics and Microsystems, Via Monteroni (Campus Ecotekne), 73100, Lecce, Italy.
出版信息
Neurosci Bull. 2018 Apr;34(2):270-282. doi: 10.1007/s12264-017-0188-0. Epub 2017 Nov 10.
Abstract
In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.
摘要
在这项研究中，我们在体内研究了非侵入性物理治疗——无线电电磁不对称传递器（REAC）对鱼藤酮（MPTP）诱导的帕金森病小鼠模型中神经炎症反应的影响。我们发现，针对神经再生目的的特定 REAC 组织优化治疗（REAC TO-RGN-N）可减轻 MPTP 诱导的黑质纹状体损伤引起的炎症反应，降低促炎分子水平并增加抗炎介质。此外，在接受 REAC TO-RGN-N 治疗的 MPTP 处理小鼠中，星形胶质细胞和小胶质细胞的激活明显减少。这些结果表明，REAC TO-RGN-N 治疗可调节促炎反应并减轻 MPTP 诱导的帕金森病中的神经元损伤。
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