Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
CNR Institute for Microelectronics and Microsystems, Via Monteroni (Campus Ecotekne), 73100, Lecce, Italy.
Neurosci Bull. 2018 Apr;34(2):270-282. doi: 10.1007/s12264-017-0188-0. Epub 2017 Nov 10.
In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.
在这项研究中，我们在体内研究了非侵入性物理治疗——无线电电磁不对称传递器（REAC）对鱼藤酮（MPTP）诱导的帕金森病小鼠模型中神经炎症反应的影响。我们发现，针对神经再生目的的特定 REAC 组织优化治疗（REAC TO-RGN-N）可减轻 MPTP 诱导的黑质纹状体损伤引起的炎症反应，降低促炎分子水平并增加抗炎介质。此外，在接受 REAC TO-RGN-N 治疗的 MPTP 处理小鼠中，星形胶质细胞和小胶质细胞的激活明显减少。这些结果表明，REAC TO-RGN-N 治疗可调节促炎反应并减轻 MPTP 诱导的帕金森病中的神经元损伤。
