Tan Phui Yee, Tan Tai Boon, Chang Hon Weng, Tey Beng Ti, Chan Eng Seng, Lai Oi Ming, Sham Baharin Badlishah, Nehdi Imededdine Arbi, Tan Chin Ping
Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia , 43400 Serdang, Selangor, Malaysia.
Chemical Engineering Discipline, School of Engineering, Monash University Malaysia , Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.
J Agric Food Chem. 2017 Dec 6;65(48):10651-10657. doi: 10.1021/acs.jafc.7b03521. Epub 2017 Nov 21.
Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1-9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic conditions. The TM were also unstable against the effect of ionic strength, with a high release (70.73 ± 0.04%) of tocotrienols even at a low sodium chloride concentration (50 mM). As for the individual isomers, δ-tocotrienol was the most sensitive to pH and ionic strength. In contrast, β-/γ-tocotrienols were the most ionic-stable isomers but more responsive toward thermal treatment. Simulated gastrointestinal model showed that the chitosan-alginate-based TM could be used to retain tocotrienols in the gastric and subsequently release them in the intestines for possible absorption.
鉴于生育三烯酚对健康有益，人们一直在持续开展关于这些化合物的包封和递送研究。在本研究中，我们将生育三烯酚包封于壳聚糖-海藻酸盐微胶囊中，并评估了它们的释放特性。总体而言，这些生育三烯酚微胶囊（TM）表现出较高的热稳定性。当进行pH调节（pH 1 - 9）时，我们观察到在碱性条件下生育三烯酚的释放量最高（33.78 ± 0.18%）。TM对离子强度的影响也不稳定，即使在低氯化钠浓度（50 mM）下，生育三烯酚的释放量也很高（70.73 ± 0.04%）。至于各个异构体，δ-生育三烯酚对pH和离子强度最为敏感。相比之下，β-/γ-生育三烯酚是离子稳定性最高的异构体，但对热处理更为敏感。模拟胃肠道模型表明，基于壳聚糖-海藻酸盐的TM可用于在胃部保留生育三烯酚，并随后在肠道中释放以便可能被吸收。
