Division of Biochemistry, Department of Biology, University of Fribourg, Switzerland.
FEBS Lett. 2018 Apr;592(8):1304-1311. doi: 10.1002/1873-3468.12909. Epub 2017 Nov 24.
In their natural habitat, yeast cells are constantly challenged by changing environmental conditions and a fierce competition for limiting resources. To thrive under such conditions, cells need to adapt and divide quickly, and be able to neutralize the toxic compounds secreted by their neighbors. Proteins like the pathogen-related yeast, Pry proteins, which belong to the large CAP/SCP/TAPS superfamily, may have an important role in this function. CAP proteins are conserved from yeast to man and are characterized by a unique αβα sandwich fold. They are mostly secreted glycoproteins and have been implicated in many different physiological processes including pathogen defense, virulence, venom toxicity, and sperm maturation. Yeast members of this family bind and export sterols as well as fatty acids, and they render cells resistant to eugenol, an antimicrobial compound present in clove oil. CAP family members might thus exert their various physiological functions through binding, sequestration, and neutralization of such small hydrophobic compounds.
在自然栖息地中，酵母细胞不断受到环境条件变化和有限资源竞争的挑战。为了在这种条件下茁壮成长，细胞需要快速适应和分裂，并能够中和其邻居分泌的有毒化合物。像与病原体相关的酵母 Pry 蛋白这样的蛋白质，属于 CAP/SCP/TAPS 超家族，可能在这一功能中发挥着重要作用。CAP 蛋白从酵母到人类都是保守的，其特征是独特的 αβα 三明治折叠。它们大多是分泌的糖蛋白，与许多不同的生理过程有关，包括病原体防御、毒力、毒液毒性和精子成熟。该家族的酵母成员结合并输出甾醇和脂肪酸，并使细胞对丁香酚（一种存在于丁香油中的抗菌化合物）具有抗性。因此，CAP 家族成员可能通过结合、隔离和中和这些小疏水性化合物来发挥其各种生理功能。
