Laboratory for Marmoset Neural Architecture, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Laboratory for Marmoset Neural Architecture, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Curr Opin Neurobiol. 2018 Jun;50:1-6. doi: 10.1016/j.conb.2017.10.016. Epub 2017 Nov 7.
Although mice have been the most frequently used experimental animals in many research fields due to well-established gene manipulation techniques, recent evidence has revealed that rodent models do not always recapitulate pathophysiology of human neurological and psychiatric diseases due to the differences between humans and rodents. The recent developments in gene manipulation of non-human primate have been attracting much attention in the biomedical research field, because non-human primates have more applicable brain structure and function than rodents. In this review, we summarize recent progress on genetically-modified non-human primates including transgenic and knockout animals using genome editing technology.
虽然由于成熟的基因操作技术，老鼠在许多研究领域中一直是最常被使用的实验动物，但最近的证据表明，由于人类和啮齿动物之间的差异，啮齿动物模型并不总是能重现人类神经和精神疾病的病理生理学。最近在非人类灵长类动物基因操作方面的发展在生物医学研究领域引起了广泛关注，因为非人类灵长类动物的大脑结构和功能比啮齿动物更适用。在这篇综述中，我们总结了使用基因组编辑技术的转基因和基因敲除动物等基因修饰非人类灵长类动物的最新进展。
