Fontana Barbara D, Mezzomo Nathana J, Kalueff Allan V, Rosemberg Denis B
Laboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil.
Laboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; Graduate Program in Pharmacology, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil.
Exp Neurol. 2018 Jan;299(Pt A):157-171. doi: 10.1016/j.expneurol.2017.10.004. Epub 2017 Oct 5.
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.
斑马鱼（Danio rerio）因其遗传易处理性、分子/生理保守性、体型小、易于体内实验操作以及丰富的行为表现，已成为神经科学研究中的有力工具。斑马鱼模型和测试在遗传学研究、神经表型分析、中枢神经系统药物筛选以及模拟复杂的神经和精神疾病方面特别有用。在这里，我们讨论斑马鱼模型成功应用于模拟脑病理学各个方面的选定示例，并强调它们在研究潜在分子和遗传机制方面不断发展的效用。我们还总结了基于斑马鱼的中枢神经系统疾病建模的最新进展，并概述了可能显著改善转化神经科学和实验神经病学研究以及药物发现的新研究策略。
