Lim Seung Hoon, Ryu Chang-Woo, Tian Yunan, Jun Ji Eun, Park Soonchan, Jeong In-Kyung, Jahng Geon-Ho
Department of Neurosurgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Front Endocrinol (Lausanne). 2025 Aug 1;16:1586085. doi: 10.3389/fendo.2025.1586085. eCollection 2025.
Type 2 diabetes mellitus (T2DM) is known to adversely impact brain health, leading to cognitive decline and brain tissue volume reduction. This study aimed to assess the damage to gray-white matter junction tissue volume (gwJTV) in T2DM patients with and without carotid artery plaques, and its association with various metabolic parameters.
We conducted a cross-sectional study involving 69 T2DM patients, employing three-dimensional T1-weighted MRI scans to measure brain tissue volumes, particularly gwJTV, and analyzing blood samples for metabolic parameters. Voxel-based (VBA) and region-of-interest (ROI) analyses of gwJTV were performed to evaluate the group difference with and without carotid artery plaques and to determine correlations to metabolic biomarkers.
Voxel-based and region-of-interest analyses revealed that participants with carotid plaques had lower gwJTV than those without at the specific brain area. ROI results study further demonstrated positive associations between gwJTV and metabolic parameters such as AST, ApoB, and LDL, and negative associations with C-peptide, creatinine, and hsCRP.
Our findings suggest that gwJTV could be a valuable imaging biomarker for monitoring brain and vascular health in T2DM patients, particularly those affected by carotid atherosclerosis.
2型糖尿病（T2DM）已知会对脑健康产生不利影响，导致认知能力下降和脑组织体积减少。本研究旨在评估有无颈动脉斑块的T2DM患者的灰白质交界组织体积（gwJTV）损伤情况，及其与各种代谢参数的关联。
我们进行了一项横断面研究，纳入69例T2DM患者，采用三维T1加权磁共振成像扫描测量脑组织体积，特别是gwJTV，并分析血样中的代谢参数。对gwJTV进行基于体素（VBA）和感兴趣区域（ROI）分析，以评估有无颈动脉斑块组之间的差异，并确定与代谢生物标志物的相关性。
基于体素和感兴趣区域分析显示，有颈动脉斑块的参与者在特定脑区的gwJTV低于无斑块者。ROI结果研究进一步表明，gwJTV与AST、载脂蛋白B和低密度脂蛋白等代谢参数呈正相关，与C肽、肌酐和高敏C反应蛋白呈负相关。
我们的研究结果表明，gwJTV可能是监测T2DM患者脑和血管健康的有价值的影像学生物标志物，尤其是那些受颈动脉粥样硬化影响的患者。
