King G L, Shiba T, Oliver J, Inoguchi T, Bursell S E
Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Annu Rev Med. 1994;45:179-88. doi: 10.1146/annurev.med.45.1.179.
Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.
糖尿病血管并发症会影响微血管和大血管，主要累及视网膜、肾小球以及大血管的多个部位。本综述总结了在体内以及暴露于高糖环境的培养血管细胞中发现的异常功能。我们还讨论了为解释高血糖对血管细胞的不利影响而提出的各种生化假说。
