Institute of Home & Food Sciences, Government College University, Faisalabad, 38040, Pakistan.
Lipids Health Dis. 2017 Nov 10;16(1):211. doi: 10.1186/s12944-017-0602-7.
Cardiovascular diseases and diabetes are responsible for large number of deaths throughout the globe. Bitter gourd has the potential to become a component of the diet or a dietary supplement for diabetic and pre-diabetic patients owing to the presence of insulin like molecules. Recent investigations have suggested that bitter gourd extracts may ameliorate high fat diet induced obesity and hyperlipidemia in animal models. Moreover, its supplements in food result in lowering weight gain and visceral fat mass.
The current study was designed to investigate the nutraceutical potential of skin, flesh and whole fruit of bitter gourd cultivars against hyperglycemia and hyperlipidemia. For the purpose, various bitter gourd cultivars were procured from local market. Bio-evaluation studies were carried out on biochemical parameters using rodent experiment model.
From results, it was revealed that maximum reduction in blood glucose skin 1.06%, flesh 2.65%, whole fruit 4.29%, total cholesterol skin 6.60%, flesh 6.04%, whole fruit 6.70%, low density lipoprotein skin 5.55%, flesh 6.81%, whole fruit 6.60%, and triglycerides skin 0.04%, flesh 3.38%, whole fruit 2.02%, were observed. Moreover, insulin skin 2.14%, flesh 3.52%, whole fruit 2.73%, production was slightly enhanced with improved levels of high density lipoprotein in whole fruit of bitter gourd.
Overwhelmingly, it may be inferred here that bitter gourd holds the potential to significantly improve diabetic conditions and associated late complications with no ill effects on body organs.
心血管疾病和糖尿病是导致全球大量死亡的原因。苦瓜由于存在类似胰岛素的分子，有可能成为糖尿病和糖尿病前期患者饮食的组成部分或膳食补充剂。最近的研究表明，苦瓜提取物可能改善动物模型中的高脂肪饮食引起的肥胖和高血脂。此外，其在食物中的补充剂可降低体重增加和内脏脂肪量。
本研究旨在研究苦瓜品种的果皮、果肉和全果对高血糖和高血脂的营养潜力。为此，从当地市场采购了各种苦瓜品种。使用啮齿动物实验模型对生化参数进行了生物评价研究。
结果表明，苦瓜的果皮最大程度地降低血糖 1.06%，果肉 2.65%，全果 4.29%，总胆固醇果皮 6.60%，果肉 6.04%，全果 6.70%，低密度脂蛋白果皮 5.55%，果肉 6.81%，全果 6.60%，甘油三酯果皮 0.04%，果肉 3.38%，全果 2.02%。此外，苦瓜的果皮胰岛素 2.14%，果肉 3.52%，全果 2.73%的产生略有增加，同时高密度脂蛋白水平也有所提高。
综上所述，可以推断苦瓜具有显著改善糖尿病状况和相关晚期并发症的潜力，而对身体器官没有不良影响。
