Grotzke Jeff E, Sengupta Debrup, Lu Qiao, Cresswell Peter
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011, United States.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011, United States; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8011, United States.
Curr Opin Immunol. 2017 Jun;46:89-96. doi: 10.1016/j.coi.2017.03.015. Epub 2017 May 18.
Cross-presentation is an MHC-I antigen processing pathway that results in the presentation of peptides from exogenous viral, bacterial, parasitic, and tumor antigens and ultimately leads to priming of naïve CD8 T cells. This process involves several cellular compartments and multiple components. Successful generation of MHC-I-peptide complexes requires that these components act together in a coordinated fashion. We discuss recent findings on the source of MHC-I, the role of the TAP transporter, the importance of intracellular trafficking events, mechanisms of antigen access the cytosol, and how innate immune signals can affect presentation, with an emphasis on how these pathways compare to conventional antigen presentation and how they correlate with existing data.
交叉呈递是一种MHC-I抗原加工途径，可导致外源性病毒、细菌、寄生虫和肿瘤抗原的肽段呈递，并最终引发初始CD8 T细胞的激活。这一过程涉及多个细胞区室和多种成分。成功生成MHC-I-肽复合物需要这些成分以协调的方式共同发挥作用。我们讨论了关于MHC-I来源、TAP转运体的作用、细胞内运输事件的重要性、抗原进入胞质溶胶的机制以及固有免疫信号如何影响呈递的最新研究结果，重点关注这些途径与传统抗原呈递的比较以及它们与现有数据的相关性。
