Zhang Xiaokun, Wu Ye, Lin Jiayi, Lu Shengxin, Lu Xinchen, Cheng Aoyu, Chen Hongzhuan, Zhang Weidong, Luan Xin
Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Acta Pharm Sin B. 2024 Sep;14(9):3818-3833. doi: 10.1016/j.apsb.2024.05.013. Epub 2024 May 13.
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy. As vital biological mediators, peptides with high tissue penetration and superior selectivity offer significant promise for enhancing cancer immunotherapies (CITs). However, physicochemical peptide features such as conformation and stability pose challenges to their on-target efficacy. This review provides a comprehensive overview of recent advancements in therapeutic peptides targeting key steps of the cancer-immunity cycle (CIC), including tumor antigen presentation, immune cell regulation, and immune checkpoint signaling. Particular attention is given to the opportunities and challenges associated with these peptides in boosting CIC within the context of clinical progress. Furthermore, possible future developments in this field are also discussed to provide insights into emerging CITs with robust efficacy and safety profiles.
免疫疗法在癌症治疗中具有实现持久效力和长期生存机会的巨大潜力。作为重要的生物介质，具有高组织穿透性和卓越选择性的肽为增强癌症免疫疗法（CITs）带来了巨大希望。然而，肽的物理化学特性，如构象和稳定性，对其靶向疗效构成了挑战。本综述全面概述了靶向癌症免疫循环（CIC）关键步骤的治疗性肽的最新进展，包括肿瘤抗原呈递、免疫细胞调节和免疫检查点信号传导。特别关注了这些肽在临床进展背景下促进CIC方面的机遇和挑战。此外，还讨论了该领域未来可能的发展，以深入了解具有强大疗效和安全性的新兴CITs。
