Charest Mathieu, Pressacco Josephine, Thomas-Gittens Jaramie
Nuclear Medicine Department, Hôpital du Sacré-Coeur de Montréal, Canada.
Radiology Department, Hôpital du Sacré-Coeur de Montréal, Canada.
J Nucl Med Technol. 2017 Nov 10. doi: 10.2967/jnmt.117.199927.
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed.
一名25岁已知患有1型神经纤维瘤病的女性，因前纵隔有一巨大肿块而接受检查。F18 - FDG PET - CT显示前纵隔有一放射性示踪剂摄取活跃的肿块，SUVmax为4.3，且有一个低活性中心。随后进行的碘 - 123 MIBG SPECT - CT检查未显示任何摄取，从而在很大程度上排除了副神经节瘤或神经母细胞瘤的诊断。最终病理诊断为心包恶性外周神经鞘瘤（MPNST），伴有软骨肉瘤和血管肉瘤分化区域。
