2nd Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 33 Badachu Road, Shijingshan District, 100144, Beijing, China.
BMC Surg. 2023 Jun 10;23(1):157. doi: 10.1186/s12893-023-02067-7.
Neurofibromatosis (NF) is an inherited disease and a benign tumor originating from nerve sheath cells. Neurofibromatosis type I (NF1) is the most common type, and most cases are characterized by neurofibromas. Neurofibromas in NF1 are mainly treated by surgery. Our study explores the risk factors for intraoperative hemorrhage in Type I neurofibromatosis patients who underwent neurofibroma resection.
A cross-sectional comparison of the patients who had undergone resection of neurofibroma for NF1. Data regarding patient characteristics and data about operative outcomes were recorded. The definition of intraoperative hemorrhage group was the intraoperative blood loss greater than 200 ml.
Of 94 eligible patients, 44 patients were in the hemorrhage group and 50 patients were in the non-hemorrhage group. Multiple logistic regression analysis demonstrated that the area of excision, classification, surgical site, primary surgical, and organ deformation were significant independent predictors of hemorrhage.
Early treatment can reduce the tumor cross-sectional area, avoid organ deformation, and reduce intraoperative blood loss. For plexiform neurofibroma or neurofibroma of the head and face, the amount of blood loss should be predicted correctly, and preoperative evaluation and blood preparation should be paid more attention to.
神经纤维瘤病（NF）是一种遗传性疾病，起源于神经鞘细胞的良性肿瘤。神经纤维瘤病 I 型（NF1）是最常见的类型，大多数病例的特征是神经纤维瘤。NF1 中的神经纤维瘤主要通过手术治疗。我们的研究探讨了接受神经纤维瘤切除术的 NF1 患者术中出血的危险因素。
对接受 NF1 神经纤维瘤切除术的患者进行横断面比较。记录患者特征数据和手术结果数据。术中出血组的定义为术中出血量大于 200ml。
94 例符合条件的患者中，44 例为出血组，50 例为非出血组。多因素逻辑回归分析表明，切除面积、分类、手术部位、初次手术和器官变形是出血的显著独立预测因素。
早期治疗可以减少肿瘤的横截面积，避免器官变形，减少术中出血量。对于丛状神经纤维瘤或头面部神经纤维瘤，应正确预测出血量，并应更加重视术前评估和备血。
