Tanii H, Kurosaka Y, Hayashi M, Hashimoto K
Department of Hygiene, School of Medicine, Kanazawa University, Japan.
Exp Neurol. 1989 Jan;103(1):64-7. doi: 10.1016/0014-4886(89)90186-6.
A single oral dose of allylnitrile (ALN) in mice pretreated with CCl4 induced behavioral abnormalities such as circling, hyperactivity, and head twitching, which lasted for a 4-month observation period. Histopathologically hemorrhage, demyelinated fibers and necrotic neurons were observed in the midbrain and pons 40 to 50 days after the administration of ALN. The head twitching was either reduced by treatment with serotonin and dopamine antagonists or enhanced by a serotonin releaser, suggesting that both serotonin and dopamine systems are involved in the behavioral abnormalities by ALN. These disorders by ALN may be used as an animal model of the dyskinetic syndrome.
在经四氯化碳预处理的小鼠中，单次口服烯丙腈（ALN）会诱发行为异常，如转圈、多动和头部抽搐，这些异常在长达4个月的观察期内持续存在。组织病理学检查发现，在给予ALN后40至50天，中脑和脑桥出现出血、脱髓鞘纤维和坏死神经元。头部抽搐要么通过血清素和多巴胺拮抗剂治疗而减轻，要么通过血清素释放剂而增强，这表明血清素和多巴胺系统都参与了ALN所致的行为异常。ALN引起的这些病症可用作运动障碍综合征的动物模型。
