Bardosi A
Department of Neuropathology, University of Göttingen, Federal Republic of Germany.
Exp Neurol. 1989 Feb;103(2):123-34. doi: 10.1016/0014-4886(89)90073-3.
Two proximal branches of the rat facial nerve were transected and anastomosed end-to-end within a silicone tube, each of them being exposed to a massive invasion of ascending regenerating axons. The proximal nerves contained extremely large bundles of regenerated fibers, often associated with preexistent "parent fibers." The bundles showed many signs of rash and disordered cell proliferation and myelination. These included multiple Schwann cells surrounded by a common basement membrane, occurrence of different phases of myelination and even myelination of two axons by one Schwann cell. There was no evidence of mitogenic signals for fibrocytes. This model may be used for studying the mitogenic effect of axons on Schwann cells. It also suggests that so-called "groups of regenerating fibers" in neuropathy are caused by Schwann cell recruitment.
大鼠面神经的两条近端分支被切断，并在硅胶管内进行端端吻合，每一条分支都暴露于大量上行再生轴突的侵入之下。近端神经包含极大量的再生纤维束，常常与先前存在的“母纤维”相关联。这些纤维束显示出许多紊乱和无序的细胞增殖及髓鞘形成迹象。这些迹象包括多个施万细胞被共同的基底膜所包围、出现不同阶段的髓鞘形成，甚至一个施万细胞对两条轴突进行髓鞘形成。没有证据表明存在对成纤维细胞的促有丝分裂信号。该模型可用于研究轴突对施万细胞的促有丝分裂作用。它还表明，神经病变中所谓的“再生纤维群”是由施万细胞募集引起的。
