Department of Physiology, and the Center for Molecular Medicine and Genetics, Wayne State University, 4116 Scott Hall, 540 E. Canfield, Detroit, MI, 48201, USA.
Transl Stroke Res. 2018 Jun;9(3):251-257. doi: 10.1007/s12975-017-0586-7. Epub 2017 Nov 10.
In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.
在这篇迷你综述中，我们概述了 mRNA 结合蛋白及其相关信使核糖核蛋白复合物（mRNP）在几种疾病状态中的作用，并将这些信息应用于脑缺血的病理生理学。得出的一个结论是，mRNP 可能在蛋白毒性中起因果作用，而不仅仅是被动的靶标。针对 mRNP 的缺血治疗方法比针对单一途径的治疗方法具有优势，但在设计治疗方法时需要考虑 mRNP 的行为。
