缺血再灌注损伤中的 N-甲基腺苷（m6A）甲基化。

Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510000, China.

Cell Death Dis. 2020 Jun 24;11(6):478. doi: 10.1038/s41419-020-2686-7.

Ischemia-reperfusion (I/R) injury is common during surgery and often results in organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well understood. RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such as immunity, response to DNA damage, tumorigenesis, metastasis, stem cell renewal, fat differentiation, circadian rhythms, cell development and differentiation, and cell division. Research on RNA modifications, specifically N6-methyladenosine (mA), have confirmed that they are involved in the regulation of organ I/R injury. In this review, we summarized current understanding of the regulatory roles and significance of mA RNA methylation in I/R injury in different organs.

缺血再灌注（I/R）损伤在手术中很常见，通常会导致器官功能障碍。I/R 损伤的机制复杂、多样，目前尚不完全清楚。RNA 甲基化是一种新的表观遗传修饰，参与调节各种生物学过程，如免疫、对 DNA 损伤的反应、肿瘤发生、转移、干细胞更新、脂肪分化、昼夜节律、细胞发育和分化以及细胞分裂。对 RNA 修饰的研究，特别是 N6-甲基腺苷（mA）的研究，证实了它们在调节器官 I/R 损伤中的作用。在这篇综述中，我们总结了目前对 mA RNA 甲基化在不同器官 I/R 损伤中的调节作用和意义的认识。