Eldridge F L, Paydarfar D, Scott S C, Dowell R T
Department of Medicine, University of North Carolina, Chapel Hill 27599.
Exp Neurol. 1989 Feb;103(2):179-85. doi: 10.1016/0014-4886(89)90080-0.
We induced generalized seizures by cortical injection of penicillin in anesthetized, paralyzed cats. After they had developed recurrent ictal-interictal ECoG cycling and fictive tonic-clonic motor convulsions (status epilepticus), we studied the effect of systemically administered neuropharmacological agents on the seizure cycling. Antagonists of adenosine receptors, theophylline and 8-cyclopentyltheophylline, increased the cycle period due to marked prolongation of duration of ictal discharge, often to more than 30 min. Dipyridamole, an inhibitor of adenosine reuptake, lengthened the interictal phase of the seizure with no effect on ictal duration. Antagonists of gamma-aminobutyric acid and opioid peptides had no effect on either ictal or interictal phases nor did the nonspecific neural excitant, doxapram. These findings suggest that a major mechanism of ictal-interictal cycling during status epilepticus is the alternating accumulation during the ictal phase and clearance during the interictal phase of the inhibitory neurochemical, adenosine.
我们通过在麻醉、麻痹的猫的皮层注射青霉素来诱发全身性癫痫发作。在它们出现反复的发作期 - 发作间期脑电图循环和假性强直 - 阵挛性运动惊厥（癫痫持续状态）后，我们研究了全身给药的神经药理学药物对癫痫发作循环的影响。腺苷受体拮抗剂茶碱和8 - 环戊基茶碱由于发作期放电持续时间显著延长，常常延长至超过30分钟，从而增加了循环周期。腺苷再摄取抑制剂双嘧达莫延长了癫痫发作的发作间期，对发作期持续时间无影响。γ - 氨基丁酸和阿片肽拮抗剂对发作期或发作间期均无影响，非特异性神经兴奋剂多沙普仑也无影响。这些发现表明，癫痫持续状态期间发作期 - 发作间期循环的一个主要机制是抑制性神经化学物质腺苷在发作期积累而在发作间期清除的交替过程。
