Soška Vladimír, Kyselák Ondřej
Vnitr Lek. 2017 Fall;63(10):663-666.
Statins are key drugs for patients in secondary prevention of cardiovascular disease, as well as for primary prevention patients at high or very high risk of fatal cardiovascular events. However, long-term compliance of patients to statin therapy is relatively low, decreasing with the time of statin use; moreover a significant proportion of patients stop statins medication over the course of several years. To the early termination of statin treatment often contributes apprehension of the occurence of statin´s side effects (i.g. increased creatine kinase in the blood and muscle problems), although these symptoms are usually not causally related to statin therapy. To the low compliance may also contribute administration of statins in the evening hours, as well as the fear of developing diabetes or drug interactions. The above issues are discussed in the text of this article.Key words: compliance - creatinkinase - diabetes mellitus -LDL-cholesterol - statins.
他汀类药物是心血管疾病二级预防患者以及发生致命心血管事件高风险或极高风险的一级预防患者的关键药物。然而，患者对他汀类药物治疗的长期依从性相对较低，且随他汀类药物使用时间的延长而降低；此外，相当一部分患者在数年的疗程中停止服用他汀类药物。他汀类药物治疗早期终止往往是由于担心出现他汀类药物的副作用（如血液中肌酸激酶升高和肌肉问题），尽管这些症状通常与他汀类药物治疗没有因果关系。他汀类药物在夜间给药以及对患糖尿病或药物相互作用的恐惧也可能导致依从性较低。本文将讨论上述问题。关键词：依从性 - 肌酸激酶 - 糖尿病 - 低密度脂蛋白胆固醇 - 他汀类药物
