Service de Pneumologie, AP-HP, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France; Univ Paris Diderot, Sorbonne Paris Cité, UMR 1153 CRESS, Biostatistics and Clinical Epidemiology Research Team, Paris F-75010, France.
Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D5-360, Seattle, WA 98105, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific, Campus Box 356522, Seattle, WA 98195-6522, USA.
Clin Chest Med. 2017 Dec;38(4):607-621. doi: 10.1016/j.ccm.2017.07.003. Epub 2017 Sep 19.
As more individuals survive their hematologic malignancies after allogeneic hematopoietic stem cell transplantation (HSCT), there is growing appreciation of the late organ complications of this curative procedure for malignant and nonmalignant hematologic disorders. Late noninfectious pulmonary complications encompass all aspects of the bronchopulmonary anatomy. There have been recent advances in the diagnostic recognition and management of bronchiolitis obliterans syndrome, which is recognized as a pulmonary manifestation of chronic graft-versus-host disease. Organizing pneumonia and other interstitial lung diseases are increasingly recognized. This article provides an update on these entities as well as pleural and pulmonary vascular disease after allogeneic HSCT.
随着越来越多的异基因造血干细胞移植（HSCT）后血液病患者存活下来，人们越来越认识到这种治疗恶性和非恶性血液病的方法的晚期器官并发症。晚期非传染性肺部并发症涵盖了支气管肺解剖的各个方面。近年来，在闭塞性细支气管炎综合征的诊断识别和治疗方面取得了进展，该病被认为是慢性移植物抗宿主病的肺部表现。机化性肺炎和其他间质性肺疾病也越来越受到重视。本文就这些实体以及异基因 HSCT 后的胸膜和肺血管疾病进行了更新。
