Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA; Betty and Guy Beatty Center for Integrated Research, Inova Health System, 3300 Gallows Road, Falls Church, VA 22042, USA.
Center for Outcomes Research in Liver Disease, 2411 I Street NW, Washington, DC 20037, USA.
Clin Liver Dis. 2018 Feb;22(1):1-10. doi: 10.1016/j.cld.2017.08.001. Epub 2017 Oct 14.
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with an increasing global prevalence associated with tremendous clinical, economic, and health-related quality-of-life burden. Clinically, NAFLD is considered the liver manifestation of metabolic syndrome. However, diagnosing NAFLD presents significant challenges due to the limited noninvasive and accurate diagnostic tools available to not only accurately diagnose nonalcoholic steatohepatitis but also to stage hepatic fibrosis, the major predictor of long-term outcomes, including mortality.
非酒精性脂肪性肝病（NAFLD）是一种慢性肝病，其全球患病率不断上升，给临床、经济和健康相关生活质量带来了巨大负担。临床上，NAFLD 被认为是代谢综合征的肝脏表现。然而，由于缺乏非侵入性和准确的诊断工具，诊断 NAFLD 存在很大的挑战，这些工具不仅要准确诊断非酒精性脂肪性肝炎，还要对肝纤维化进行分期，肝纤维化是长期预后的主要预测因素，包括死亡率。
