非酒精性脂肪性肝病的自然史——不断变化的观点。
The Natural History of Nonalcoholic Fatty Liver Disease-An Evolving View.
机构信息
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Mail Code A30, Cleveland, OH 44195, USA.
Department of Gastroenterology and Hepatology, Transplantation Center, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Mail Code A30, Cleveland, OH 44195, USA; Department of Pathobiology, Transplantation Center, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Mail Code A30, Cleveland, OH 44195, USA.
出版信息
Clin Liver Dis. 2018 Feb;22(1):11-21. doi: 10.1016/j.cld.2017.08.003.
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, and its clinical and economic burden will continue to grow with parallel increases in rates of obesity, diabetes, and the metabolic syndrome. Evolving understanding of the natural history of NAFLD suggests that these patients are at risk for disease progression to steatohepatitis, fibrosis, and cirrhosis. Recent studies also suggest that these patients are at elevated risk for cardiovascular-, malignancy-, and liver-related morbidity and mortality, although their risk for progression, decompensation, and hepatocellular carcinoma may be less than that of patients with alternative causes of chronic liver disease.
非酒精性脂肪性肝病（NAFLD）是全球慢性肝病的主要病因，随着肥胖症、糖尿病和代谢综合征发病率的上升，其临床和经济负担将继续增加。对 NAFLD 自然史的认识不断发展表明，这些患者存在疾病进展为脂肪性肝炎、纤维化和肝硬化的风险。最近的研究还表明，这些患者发生心血管疾病、恶性肿瘤和肝脏相关发病率和死亡率的风险增加，尽管与其他原因引起的慢性肝病患者相比，其进展、失代偿和肝细胞癌的风险可能较低。
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