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对抗肥胖相关肝病的营养策略:医学营养治疗在代谢功能障碍相关脂肪性肝病(MASLD)管理中的作用

Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management.

作者信息

Simancas-Racines Daniel, Annunziata Giuseppe, Verde Ludovica, Fascì-Spurio Federica, Reytor-González Claudia, Muscogiuri Giovanna, Frias-Toral Evelyn, Barrea Luigi

机构信息

Universidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Quito, 170527, Ecuador.

Facoltà di Scienze Umane, della Formazione e dello Sport, Università Telematica Pegaso, Via Porzio, Centro Direzionale, Isola F2, Naples, 80143, Italy.

出版信息

Curr Obes Rep. 2025 Jan 11;14(1):7. doi: 10.1007/s13679-024-00597-6.

Abstract

PURPOSE OF REVIEW

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine the effectiveness of specific nutritional strategies in preventing and treating this obesity-linked liver disease.

RECENT FINDINGS

Emerging evidence underscores the benefits of the Mediterranean diet, low-carbohydrate diets, and intermittent fasting in reducing liver fat, improving insulin sensitivity, and mitigating inflammation. Supplementing with vitamin E, omega-3 fatty acids, and silymarin can potentially reduce liver fibrosis and promote liver health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, and nutraceutical supplementation. Integrating these strategies with lifestyle modifications, including regular physical activity, offers a comprehensive approach to improving metabolic and liver outcomes in patients with MASLD. Further research is needed to refine and personalize these therapeutic interventions.

摘要

综述目的

本叙述性综述探讨医学营养治疗(MNT)在管理代谢相关脂肪性肝病(MASLD,以前称为非酒精性脂肪性肝病)中的作用。其目的是研究特定营养策略在预防和治疗这种与肥胖相关的肝病方面的有效性。

最新发现

新出现的证据强调了地中海饮食、低碳水化合物饮食和间歇性禁食在减少肝脏脂肪、改善胰岛素敏感性和减轻炎症方面的益处。补充维生素E、ω-3脂肪酸和水飞蓟素可能会减少肝纤维化并促进肝脏健康。MNT是管理MASLD的关键干预措施,强调饮食模式、热量限制和营养补充剂。将这些策略与生活方式改变(包括规律的体育活动)相结合,为改善MASLD患者的代谢和肝脏结局提供了一种全面的方法。需要进一步研究来完善和个性化这些治疗干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7d6/11724794/4d4b8f283f6e/13679_2024_597_Fig1_HTML.jpg

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