Department of Internal Medicine, Virginia Commonwealth University School of Medicine, MCV Box 980341, Richmond, VA 23298-0341, USA.
Department of Internal Medicine, Virginia Commonwealth University School of Medicine, MCV Box 980341, Richmond, VA 23298-0341, USA.
Clin Liver Dis. 2018 Feb;22(1):121-132. doi: 10.1016/j.cld.2017.08.009.
Nonalcoholic fatty liver disease is the most common cause of chronic liver disease in North America and is growing as a cause of chronic liver disease in many other parts of the world as well. It has 2 principal clinical-pathologic phenotypes: (1) nonalcoholic fatty liver and (2) nonalcoholic steatohepatitis. The development of both phenotypes is tightly linked to excess body weight and insulin resistance. This review discusses the emerging tools for the analysis of the microbiome, their limitations, and the existing literature with respect to the intestinal microbiome and their role in nonalcoholic fatty liver.
非酒精性脂肪性肝病是北美最常见的慢性肝病病因，在世界上许多其他地区也逐渐成为慢性肝病的病因之一。它有两种主要的临床病理表型：（1）非酒精性脂肪肝和（2）非酒精性脂肪性肝炎。这两种表型的发展都与超重和胰岛素抵抗密切相关。这篇综述讨论了用于分析微生物组的新兴工具、它们的局限性以及关于肠道微生物组及其在非酒精性脂肪性肝病中的作用的现有文献。
