Center of Investigation of Endocrinology and Nutrition, Clinico Universitario, University of Valladolid, Valladolid Group of Nutrition and Obesity, SCLEDYN, Spain; Medicine School, Dept Endocrinology and Nutrition H(a), Clinico Universitario, University of Valladolid, Valladolid Group of Nutrition and Obesity, SCLEDYN, Spain; Groups of Nutrition and Obesity SCLEDYN, Spain.
Groups of Nutrition and Obesity SCLEDYN, Spain.
Clin Nutr. 2018 Dec;37(6 Pt A):2144-2148. doi: 10.1016/j.clnu.2017.10.013. Epub 2017 Nov 2.
Some GLP-1 receptor studies have identified polymorphisms in the GLP-1 receptor gene that might be related to different cardiovascular risk factors.
Our aim was to investigate the allelic distribution of rs6923761 GLP-1 receptor polymorphism in a geographic area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients.
A sample of 341 obese subjects (body mass index ≥ 30 kg/m) was analyzed. Fasting blood glucose, C-reactive protein (CRP), plasma insulin, insulin resistance (HOMA-IR), and lipid profile were determined. Anthropometric parameters, dietary intake and blood pressure were recorded.
One hundred and forty three patients (42.0%) had the genotype GG (wild-type group) and one hundred and ninety eight (58.0%) patients were A carriers: GA (164 patients, 48.1%) or AA (34 patients, 9.9%) (mutant-type group). Valladolid and Segovia health areas had the lowest percentage of wild type genotype and G allelic (than other Health Areas). Burgos Health Area had a higher percentage of wild-type genotype. In wild-type group (GG genotype), BMI (0.9 ± 1.3 kg/m; p < 0.05), weight (3.3 ± 1.1 kg; p < 0.05), fat mass (2.5 ± 1.1 kg; p < 0.05), waist to hip ratio (0.02 ± 0.005 cm; p < 0.05), waist circumference (2.8 ± 1.1 cm; p < 0.05), triglycerides (14.4 ± 3.3 mg/dl; p < 0.05) insulin (3.1 ± 1.0 mg/dl; p < 0.05) and HOMA-IR (1.2 ± 0.9 mg/dl; p < 0.05) were higher than A allele carriers. In non A allele carriers, lower HDL cholesterol levels than A allele carriers (6.4 ± 2.3 mg/dl; p < 0.05) were found.
Data from our study revealed different allelic distribution in this geographic area, with better parameters (Body mass index, weight, fat mass, waist circumference, triglycerides, insulin, HOMA-IR and HDL cholesterol) in A allele carriers than in non A allele carriers.
一些 GLP-1 受体研究已经确定 GLP-1 受体基因中的多态性可能与不同的心血管危险因素有关。
我们的目的是调查西班牙卡斯蒂利亚-莱昂社区（西班牙的一个地区）中 GLP-1 受体 rs6923761 多态性的等位基因分布，并评估该多态性对肥胖患者空腹状态下肥胖人体重参数和心血管危险因素的影响。
分析了 341 名肥胖患者（体重指数≥30kg/m）。测定空腹血糖、C 反应蛋白（CRP）、血浆胰岛素、胰岛素抵抗（HOMA-IR）和血脂谱。记录了人体测量参数、饮食摄入和血压。
143 名患者（42.0%）为 GG 基因型（野生型组），198 名患者为 A 携带者：GA（164 名，48.1%）或 AA（34 名，9.9%）（突变型组）。巴利亚多利德和塞戈维亚卫生区的野生型基因型和 G 等位基因（与其他卫生区相比）的百分比最低。布尔戈斯卫生区的野生型基因型比例较高。在野生型组（GG 基因型）中，BMI（0.9±1.3kg/m；p<0.05）、体重（3.3±1.1kg；p<0.05）、脂肪量（2.5±1.1kg；p<0.05）、腰臀比（0.02±0.005cm；p<0.05）、腰围（2.8±1.1cm；p<0.05）、甘油三酯（14.4±3.3mg/dl；p<0.05）、胰岛素（3.1±1.0mg/dl；p<0.05）和 HOMA-IR（1.2±0.9mg/dl；p<0.05）均高于 A 等位基因携带者。在非 A 等位基因携带者中，HDL 胆固醇水平低于 A 等位基因携带者（6.4±2.3mg/dl；p<0.05）。
本研究的数据显示，在该地理区域存在不同的等位基因分布，A 等位基因携带者的参数（体重指数、体重、脂肪量、腰围、甘油三酯、胰岛素、HOMA-IR 和 HDL 胆固醇）优于非 A 等位基因携带者。
